Фармацевтски факултет Скопје

Detailed survey of the subject

ФФИФ02 - Phytochemistry (90)

Institute:

INSTITUTE OF PHARMACOGNOSY

Terms:

Semester 5

Professor:

PhD SVETLANA KULEVANOVA
- MARIJA KARAPANDZHOVA

Hours:

3+3

Credits:

6.5

Final grade:

писмен испит

Options:

OPTION - general

Subject	Phytochemistry
Code	FFIF02
Type of Subject	compulsory
Credits	6.5 CRs
Prerequest	Bioorganic chemistry (FFIX06), Instrumental pharmaceutical analyses (FFIX07), Pharmaceutical botany (FFIF04)
Aim	The study of the basic metabolic pathways in plant biochemistry and the origin of secondary metabolites (biomolecules); the chemistry of natural plant raw materials, physiologically active substances and secondary metabolites; classification, distribution, biological activity and importance in the pharmacy of biomolecules; procedures in qualitative and quantitative chemical analyses of biomolecules following the principles of isolation, determination and identification; examination methods in biogenetic studies.
Brief Program	Theory: the general section comprises: chemical and elementary plant composition; products of primary metabolism and basic metabolite pathways with the origin of secondary metabolites; the special section includes: products of primary metabolism: carbohydrates, lipids, proteins, enzymes and nucleic acids from the aspect of biosynthesis, chemistry, plant functions with principles for their chemical analysis and meaning in pharmacy; the biosynthetic origin of special groups of secondary plant metabolites with classification, chemical characteristics, meaning in pharmacy and procedures for their chemical examination; major classes of phenol compounds: phenols with simple structure most frequently originating from pirogalol, floroglucinol, katehol, resorcinol and hydrohinon; more complex phenol compounds with C6C3 nucleus: lignums, coumarines and hormones; metabolites with C6C3C6 nucleus: flavonoids, neoflavonoids, isoflavonoids; tannins; hinons, naphthohinons, antrahinons and related compounds; isoprenoids (terpenoid and steroid); ethereal oils; resins and balsams; saponins; cardiotonic heterosides; nitrogen compounds: amines, amides; cyanogenic heterosides; alkaloids; sulfur compounds. The interconnection of biochemical processes in plants.
Practice	To master the analytical procedures and techniques for chemical examination of plant drugs and secondary metabolites with special pharmaceutical importance; kinds and ways of extraction procedure; chemical test application, spectroscopic and chromatographic techniques of separation, isolation, determination and identification of active constituents of special interest.; informative scanning of ethnographic, biological and chemical data.
Literature	Farmakognozija, fitohemija i prirodni lekoviti i aromati~ni surovini, Svetlana Kulevanova, Kultura, Skopje, 2005; Osnovi farmakognozije, Nada Kova~evi}, Univerzitet u Beogradu, Beograd, 2000; Farmakognozija, Ivan Asenov i Stefan Nikolov, Medicina i fiskultura, Sofija, 1988; Pharmacognosy, Trease and Edans; Plant drug analysis, H. Wagner et al., SV-Berlin; Phytochemical Methods, J. R. Hrborne, C&H
Method of Learning	5th term: theory 3 hours per week (45 hrs), practice 3 hours per week (45 hrs) (total: 90 hrs).
Evaluation and Grading	OPTION 2

Structure

Subjects

Teaching Activities

© All rights reserved, Farmaceutical faculty, 2006, Web master VESTEL